مشخصات مقاله

مشخصات مقاله
Serum Asymmetric Dimethylarginine Concentration in Two Models of Experimentally Induced Hypertension عنوان مقاله:
Original Article نوع مقاله:
سایر موارد (درجه 3) اعتبار مقاله:
PHYSIOLOGY موضوع مقاله:

ISRN Hypertension نام کامل مجله:
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2013-01-25 تاریخ انتشار:
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خلاصه مقاله
Introduction:Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NO synthase. Elevated ADMA has been demonstrated in cardiovascular risk factors such as hyperlipidemia or diabetes, however, there is a controversy on the effect of hypertension on serum ADMA concentration. The aim of this study was to evaluate the effect of two models of hypertension on serum ADMA concentrations and whether the changes of serum ADMA concentrationsare reversible by removing the cause of hypertension. Materials and Methods:48 male wistar rats were randomly assigned into four groups: control, Deoxycorticosterone Acetate (DOCA)-Salt, sham, two kidneys One clip (2K1C) (n=12 each). After 12 weeks, in half of the animals in each group (n=6 each), serums were taken and direct blood pressure was measured. To investigate the effect of reversal of hypertension, DOCAinjection was withdrawed and the animals received tap waterinstead of NaCl 1% solutionand in 2K1C group, renal clips were removed. After 12 weeks, direct blood pressure was measured and blood samples were taken. Results: Serum ADMA concentration in DOCA-Salt hypertensive group was slightly higher than control, although it was not statistically significant. In 2K1C hypertensive group, serum ADMA concentration was significantly elevated compare to sham group (p˂0.05). Unclipping and reversal of hypertension returned serum ADMA level to sham group. There was a weak positive correlation between systolic blood pressure and serum ADMA concentration. Conclusion: it seems that increased serum ADMA concentration during hypertension is dependent on the model of hypertension, and removing the cause of hypertension could reduce it.
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