مشخصات مقاله

مشخصات مقاله
ELEVATED SERUM LEVELS OF CELL DEATH CIRCULATING BIOMARKERS, M30 AND M65, IN PATIENTS WITH β-THALASSEMIA MAJOR عنوان مقاله:
Brief Communication, Rapid Communication, Short Communication نوع مقاله:
نمایه شده در بانک‌های اطلاعاتی معتبر (درجه 1) اعتبار مقاله:
HEMATOLOGY موضوع مقاله:

Hemoglobin نام کامل مجله:
23600495 PMID:
0.89 Impact Factor:
2013-01-16 تاریخ انتشار:
0363-0269 ISSN چاپی:
1532-432X ISSN الکترونیک:
37 شماره جلد:
4 شماره نسخه:
404 شماره صفحه شروع:
Label لینک مقاله:
شماره طرح پژوهشی:
5 نوع طرح پژوهشی:

خلاصه مقاله
Deposition of iron in visceral organs, mainly in the liver, causes tissue damage in β-thalassemia major (β-TM) patients. Keratin 18 (K18) represents one of the major caspase substrates during apoptosis of hepatocytes. To better characterize the hepatic apoptosis and/or necrosis in β-thal patients, the circulating levels of M65 (soluble intact K18) and M30 (the caspases-generated K18 fragment) were measured in 40 β-TM patients and compared with 40 healthy controls. The ratio of M30/M65 (caspase-cleaved to total K18) was also determined in thalassemic and normal subjects. Results of the ELISA assays revealed that the serum levels of hepatocyte death markers, M65 and M30, were significantly increased in β-thal patients compared to healthy controls (p <0.0001). M30 serum levels were also positively correlated with the serum levels of liver transaminases including aspartate aminotransferase (AST) (r ¼ 0.337, p ¼ 0.047) and alanine aminotransferase (ALT) (r ¼0.391, p ¼ 0.02).
std home testing kits open std test online
so your wife cheated brokenwrenchbrewing.com wives who want to cheat
cheat on wife developersalley.com why married men cheat on their wives
cheat on wife developersalley.com why married men cheat on their wives
how to tell if wife has cheated why women cheat with married men why do guys cheat
what is infidelity open infidelity in marriage
printable coupons free rkuipers.nl coupons for prescription medications
wifes who cheat how to spot a cheater how many guys cheat
phone spy for android read spy cell phone app free
can i take antabuse and naltrexone can i take antabuse and naltrexone can i take antabuse and naltrexone
acheter viagra naturel http://acheterviagraenfrance.com/naturel acheter viagra naturel